RELATIONSHIP BETWEEN VOLUME OF DISTRIBUTION OF ATRACURIUM AND BODY WEIGHT
Open Access
- 1 April 1993
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 70 (4) , 443-445
- https://doi.org/10.1093/bja/70.4.443
Abstract
We have determined the central and steady state volumes of distribution of atracurium 0.25 mg kg-1 in 41 healthy adult patients. Volume of distribution, corrected for body weight (ml kg-1)r correlated negatively with body weight (r = −0.612 for central volume of distribution; r = −0.737 for the steady state volume of distribution). When expressed as an absolute volume, neither central nor steady state volume of distribution correlated significantly with body weight (r = 0.120 and r = 0.131, respectively). These data cast doubt upon the necessity for the dose of atracurium to be related to body weight in the healthy adult population. (Br. J. Anaesth. 1993; 70: 443–445)Keywords
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