Conformationally constrained analogues of diacylglycerol (DAG). Part 19: Asymmetric syntheses of (3R)- and (3S)-3-hydroxy-4,4-disubstituted heptono-1,4-lactones as protein kinase C (PK-C) ligands with increased hydrophilicity
- 1 June 2002
- journal article
- Published by Elsevier in Tetrahedron
- Vol. 58 (26) , 5335-5345
- https://doi.org/10.1016/s0040-4020(02)00477-5
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Diacylglycerol (DAG)-lactones, a New Class of Protein Kinase C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCαJournal of Biological Chemistry, 2002
- Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between sn-1 and sn-2 Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme SpecificityJournal of Medicinal Chemistry, 2001
- Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer ChemotherapyCurrent Pharmaceutical Design, 2001
- Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular InteractionsChemical Reviews, 2001
- Conformationally Constrained Analogues of Diacylglycerol (DAG). 16. How Much Structural Complexity Is Necessary for Recognition and High Binding Affinity to Protein Kinase C?Journal of Medicinal Chemistry, 2000
- Structure/Activity Relationships of Polyfunctional Diterpenes of the Tigliane TypeEuropean Journal of Biochemistry, 1996
- Conformationally Constrained Analogues of Diacylglycerol. 12. Ultrapotent Protein Kinase C Ligands Based on a Chiral 4,4-Disubstituted Heptono-1,4-lactone TemplateJournal of Medicinal Chemistry, 1996
- Synthesis of (-)-Aristeromycin from D-glucoseTetrahedron, 1990
- Branched-chain Sugars V. Stereoselective Synthesis of 3-C- and 5-C-Methyl-d-glucoses, and 5-C-Methyl-l-idose DerivativesBulletin of the Chemical Society of Japan, 1976
- Structure determination of the new tetracyclic diterpene ingenol-triacetate with triple product methodsTetrahedron Letters, 1970