Prevalence of two different genes encoding NorA in 23 clinical strains of Staphylococcus aureus
Open Access
- 1 July 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 46 (1) , 145-146
- https://doi.org/10.1093/jac/46.1.145
Abstract
© 2000 The British Society for Antimicrobial ChemotherapySir,The mechanism of resistance to quinolones in Staphylococcus aureus results from the presence of several mutations in genes encoding DNA gyrase and topoisomerase IV or from overexpression of efflux pumps, such as NorA.1,2 The most important point mutations associated with the acquisition of quinolone resistance are in the gyrA and grlA genes,1 which encode the A subunit of DNA gyrase and topoisomerase IV, respectively. NorA plays an important role in the acquisition of resistance to hydrophilic quinolones, such as norfloxacin, but does not affect the MIC of more hydrophobic quinolones.2 Some mutations have been reported in norA and have been associated with increased levels of expression of NorA.3...The DNA and the amino acid sequences of NorA have been reported by two groups, first by Yoshida et al.2 (accession number D90119) and later...Keywords
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