Quinidine-Rifampin Interaction

Publisher Website
Google Scholar
Abstract
DRUG interactions with quinidine are likely to be clinically important, since quinidine is used in the treatment and prophylaxis of potentially serious arrhythmias, and since there is a relatively narrow range between the therapeutic and toxic concentrations.1 An interaction between quinidine and the anticonvulsant drugs primidone and phenobarbital has led to a reduction in the half-life of quinidine of approximately 50 per cent.1 Enhanced quinidine elimination after hepatic-enzyme induction by the anticonvulsants was suggested as the likely mechanism. A cautious approach in determining the dosage of quinidine was urged for patients who were receiving this drug and had any change . . .

This publication has 14 references indexed in Scilit: