COMPARISON OF ELECTROCARDIOGRAPHIC RESPONSE AND DISPOSITION OF R-DISOPYRAMIDE AND S-DISOPYRAMIDE IN THE RABBIT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 41  (2) , 227-240
Abstract
Both R- and S-disopyramide prolong the QRS interval of the ECG in the rabbit. R-disopyramide is more potent than S-disopyramide at high concentrations (> 6 .mu.g/ml), but shows similar potency at low concentrations (< 6 .mu.g/ml). R-disopyramide shows an estimated intermediate hepatic extraction ratio with a plasma clearance of 31.0 .+-. 3.2 ml/min per kg that is only to a small degree concentration-dependent. S-disopyramide plasma clearance is highly concentration-dependent, with a value larger than 50 ml/min per kg at concentrations below 4 .mu.g/ml, that decreases to a value of .apprx. 30 ml/min per kg at 16 .mu.g/ml. No differences in the binding of R- and S-disopyramide to rabbit serum or rabbit serum spiked with human .alpha.1-acid glycoprotein were found.