Rat liver membranes contain a 120 kDa glycoprotein which serves as a substrate for the tyrosine kinases of the receptors for insulin and epidermal growth factor
- 9 February 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 212 (1) , 141-144
- https://doi.org/10.1016/0014-5793(87)81573-9
Abstract
The receptors for insulin and epidermal growth factor possess tyrosine‐specific protein kinase activity which may play a role in mediating the biological actions of these two peptides. We have identified a 120 kDa glycoprotein (pp120) in rat liver plasma membranes which can be phosphorylated by the insulin receptor in a cell‐free system and in intact cultured hepatoma cells. In the present report, we have demonstrated in a cell‐free system that solubilized epidermal growth factor receptors can phosphorylate tyrosine residues inpp120.Keywords
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