What is flux balance analysis?
Top Cited Papers
- 1 March 2010
- journal article
- research article
- Published by Springer Nature in Nature Biotechnology
- Vol. 28 (3) , 245-248
- https://doi.org/10.1038/nbt.1614
Abstract
Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.Keywords
This publication has 30 references indexed in Scilit:
- A protocol for generating a high-quality genome-scale metabolic reconstructionNature Protocols, 2010
- Model-driven evaluation of the production potential for growth-coupled products of Escherichia coliMetabolic Engineering, 2009
- Applications of genome‐scale metabolic reconstructionsMolecular Systems Biology, 2009
- Reconstruction of biochemical networks in microorganismsNature Reviews Microbiology, 2008
- The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coliNature Biotechnology, 2008
- Global reconstruction of the human metabolic network based on genomic and bibliomic dataProceedings of the National Academy of Sciences, 2007
- A genome‐scale metabolic reconstruction for Escherichia coli K‐12 MG1655 that accounts for 1260 ORFs and thermodynamic informationMolecular Systems Biology, 2007
- Systems approach to refining genome annotationProceedings of the National Academy of Sciences, 2006
- Optknock: A bilevel programming framework for identifying gene knockout strategies for microbial strain optimizationBiotechnology & Bioengineering, 2003
- Robustness Analysis of the Escherichia coli Metabolic NetworkBiotechnology Progress, 2000