Inhibitory Effect of the Dopamine Agonist Bromocriptine on the Postcastration Gonadotropin Rise in Women*
- 1 September 1981
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 53 (3) , 530-535
- https://doi.org/10.1210/jcem-53-3-530
Abstract
Based or stimulated gonadotropin plasma levels were measured after bilateral ovariectomy in untreated and bromocriptine (BCT)-treated normal women. BCT was orally administered from the 7th to the 14th day after ovariectomy at a dose of 3.75 mg/day. BCT significantly (P < 0.05) inhibited LH release, both basally and after LRF stimulation. Plasma FSH levels were also reduced in treated subjects, but this decrease did not reach statistical significance relative to controls. The blunted postcastration gonadotropin rise found with BCT administration suggests that pituitary gonadotropin secretion is, in part, under dopaminergic inhibitory control. (J Clin EndocrinolMetab53: 530,1981)Keywords
This publication has 1 reference indexed in Scilit:
- Dopaminergic Mechanisms and Luteinizing Hormone Secretion. I. Acute Administration of the Dopamine Agonist Bromocriptine Does Not Inhibit Luteinizing Hormone Release in Hyperprolactinemic Women*Journal of Clinical Endocrinology & Metabolism, 1980