Rules for Making Human Tumor Cells
Top Cited Papers
- 14 November 2002
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 347 (20) , 1593-1603
- https://doi.org/10.1056/nejmra021902
Abstract
The apparent complexity of the genetic, biochemical, and physiological changes in cancer cells threatens to stall the elucidation of the origins of cancer and the development of new treatments for malignant diseases. The authors propose a considerably simplified scheme in which only five alterations are required to transform cells from a normal to a malignant phenotype.Keywords
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