BONE UPTAKE OF PHOSPHATE-TC-99M VIA LABELED PLASMA-PROTEIN

  • 1 January 1980
    • journal article
    • research article
    • Vol. 19  (4) , 174-177
Abstract
The transfer of albumin into the extravascular space of bone and other tissues was evaluated in the non-adult rat and was found to be less rapid in bone than in the liver and kidneys but more rapid than in muscle. Protein binding of 99mTc increased continuously with time after injection of 99mTc-EHDP [ethane-1, hydroxy-1, diphosphate] and -PPi [pyrophosphate]. One h after administration .apprx. 20% of the plasma activity of 99mTc-EHDP and 90% of 99mTc-PPi was bound to proteins. The possibility exists that the fixation of 99mTc through protein binding in the extravascular space of bone contributes significantly to the regular bone uptake of 99mTc-phosphates, in the event that relatively unstable compounds such as 99mTc-PPi are used.

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