Aromatic fluorination with N.C.A. F‐18 fluoride: A comparative study
- 24 July 1985
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 22 (7) , 687-694
- https://doi.org/10.1002/jlcr.2580220708
Abstract
Fluorination of aromatic rings with no carrier added (n.c.a.) 18F‐fluoride was investigated using aryl triazenes and aryl iodides as substrates. Aryl triazenes give low yields of labeled under all conditions, and evidence was obtained to indicate that an inert solvent was unnecessary for the reaction. Nucleophilic substitution of aromatic iodides in DMSO was found to be a superior method of fluorination yielding up to 70% incorporation of label. The scope and limitations of this new labeling reaction are reported.Keywords
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