Telangiectatic osteogenic sarcoma

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Abstract
Of .apprx. 1000 cases of osteogenic sarcomas, 25 were diagnosed as telangiectatic osteogenic sarcomas. Of the 25 patients involved, 16 were males and 9 were females, and their ages ranged from 6-49 yr. Six patients had pathologic fracture. The lesions were typically located centrally and usually in the distal femur or proximal humerus and roentgenographically were large and purely lytic with destruction of the cortex. Grossly, the lesions were cystic and contained clotted blood. Histologically, cystic spaces that contained blood were lined with anaplastic spindle cells and benign giant cells. Sometimes there were so few malignant cells that diagnosis was difficult. Usually, fine, lacelike osteoid was present. Of the 25 patients, 23 died of metastatic disease, and another developed pulmonary metastasis 11 mo. after amputation. Only 1 patient survived for more than 5 yr. He has developed pneumothorax. Data from this series suggest that the outlook in telangiectatic osteogenic sarcoma is more bleak than conventional osteosarcoma.

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