The Effects of Bile Acids on Colonic Motility in the Rabbit

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Abstract
The content of rabbit colon was examined and contained secondary bile acid deoxycholate. Infusions of sodium deoxycholate stimulated colonic motor activity, but the infusion of primary bile acid sodium glycocholate did not have this effect. Infusions of control amounts of distilled deionized water and isotonic saline were not followed by a significant change in motor activity. Histological damage was caused by 15 mmol/l solutions but was not severe till above 24 mmol/l. Mucosal damage probably produced motor activity and was discounted by damage present in rabbits treated by sodium glycocholate with no observed motor response. The secondary bile acid, sodium deoxycholate, could probably have a role in the production of colonic motor activity in the rabbit.

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