EFFECT OF ANAESTHETIC AGENTS ON BILE FLOW AND BILIARY EXCRETION OF 131 I- CHOLYLGLYCYLTYROSINE IN THE RAT †

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Abstract
We have compared in the rat the effects of i.v. anaesthetic agents on bile flow rate and on the biliary excretion of a novel bile acid, 131l-cholylglycyltyrosine (131l-cholylgly.tyr.). Etomidate 1-mg bolus and 2-mg h−1 infusion, Althesin 3-mg bolus and 14.5-mg h−1 infusion and propofol 3.3-mg bolus and 3.3-mg h−1 were given via a tail vein cannula and pentobarbitone 50 mg kg−1 was given by the intraperitoneal route, to groups of six rats. Each animal received only one anaesthetic agent. One hour after cannulation of the common bile duct, 131l-cholylgly.tyr. 5 μCi was injected into the jugular vein and bile was collected every 1 min for 10 min. The mean (SD) percentage cumulative biliary excretion of 131l-cholylgly.tyr. at the end of 10 min was: propofol group 74.1 (5.2)% Althesin group 82.3 (2.2)%; etomidate group 69.4 (17.6)%; pentobarbitone group 76.4 (3.2)%. Propofol and Althesin were relatively more choleretic, causing bile flow rates twice that produced by pentobarbitone. Only Althesin caused a significant increase in biliary excretion of 131l-cholylgly.tyr. relative to that in rats that received pentobarbitone. Bile flow rates for the respective anaesthetic techniques (μl min−1/100 g body weight) (mean (SD)) were: propofol group 14.1 (1.8); Althesin group 12.5 (1.7); etomidate 8.5 (1.4); pentobarbitone group 7.3 (1.0). There was a marked metabolic acidosis in all rats except in the propofol group, in which normal acid-base status and oxygenation were observed.

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