Hypothalamic Stimulation of ACTH Secretion

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Abstract
Both antidiuretic and oxytocic hormones of the hypothalamic -posthypophyseal system produce, when chronically injected in normal rats, a significant enlargement of the adrenal glands and a conspicuous increase of the adrenal sudanophilic material. The hormones do not produce modification in hypophysectomized animals. An inactivated preparation of antidiuretic hormone is completely ineffective. These results are consistent with the hypothesis that antidiuretic and oxytocic hormones of the hypo-thalamo-posthypophyseal system may act as neurohumoral agents linking the hypothalamus to the anterior pituitary through the portal blood flow.