Chiral aziridination of alkenes: oxidation of 3-amino-2-(1,2,2-trimethyl)propylquinazolin-4(3H)-one in the presence of alkenes
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 11,p. 834-835
- https://doi.org/10.1039/c39860000834
Abstract
Oxidation of the title N-aminoquinazolone (2) in dichloromethane in the presence of α-methylene-γ-butyrolactone gave a 1 : 1 : 3 ratio of stereoisomers (3): if the oxidation is carried out in the presence of a small quantity of trifluoroacetic acid (TFA), only one of these stereoisomers in produced in 72% yield.Keywords
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