PROGENITOR CELLS IN CANINE CYCLIC HEMATOPOIESIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 50  (6) , 1111-1120
Abstract
Granulocytic (colony-forming units in culture or CFU-c) and erythrocytic (erythropoietin-responsive cells or ERC) progenitor cells in canine cyclic hematopoiesis (CH) fluctuated over the cycle and in the same phase as one another. The ERC cycle is preceded by 3 or 4 days by a rise in serum erythroid-stimulating activity and is followed by a reticulocytosis. During the cycle CFU-c show a differential sensitivity to 2 sera, 1 normal and 1 containing elevated amounts of colony-stimulating activity. The proliferation rate of CFU-c also fluctuates from well above normal to considerably less than normal over the cycle. These results are discussed in the light of present knowledge of the pathogenesis of canine CH. These results may support the contention that CH is a disorder of hemopoietic stem cells and that the cycling of humoral factors and peripheral blood cells may follow as a consequence.