Treatment of metastatic malignant melanoma with dacarbazine, vindesine and cisplatin
Open Access
- 1 October 1989
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 60 (4) , 627-629
- https://doi.org/10.1038/bjc.1989.327
Abstract
Twenty-seven patients with disseminated malignant melanoma were treated monthly with cisplatin (CDDP) 120 mg m-2 on day 1, vindesine (VDS) 3 mg m-2 on day 2 and dacarbazine (DTIC) 250 mg m-2 on days 2-6. None of them had received prior chemotherapy. All patients are evaluable for response and toxicity. There were five (19%) complete (CR) and seven (26%) partial (PR) responses for a total response rate of 45%. We conclude that the combination of DTIC, VDS and CDDP is capable of producing a relatively high rate of response in patients with advanced metastatic malignant melanoma, but responses are short.Keywords
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