Integrated External and Interstitial Radiation Therapy for Primary Carcinoma of the Vagina

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Abstract
Patients (27) with the diagnosis of primary carcinoma of the vagina were treated by definitive radiotherapy. Patients (23) received a combination of external and interstitial 192Ir implant irradiation and 4 patients received only interstitial irradiation. Patients (21) had squamous cell carcinoma and 6 had adenocarcinoma. All patients were staged according to the FIGO [International Federation of Gynecology and Obstetrics] classification. More than 70% of patients had relatively advanced local disease and conventional intracavitary irradiation was unsuitable. Local tumor control was observed in 85% (23 of 27 patients), and 56% of the patients remain alive and free of disease for a median follow-up period of 50 mo. to a maximum follow-up period of 84 mo. Of the patients, 15% suffered from treatment-related complications.