Immunologic Monitoring of Transplant Rejection: Correlation of in vitro Assays with Morphologic Changes on Transplant Biopsy
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 22 (1-3) , 208-211
- https://doi.org/10.1159/000181450
Abstract
The assays of lymphocyte-mediated cytotoxicity (LMC), antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) were correlated with histopathologic criteria of rejection in 35 transplant biopsies. A positive LMC was seen with 6/8 biopsies showing moderate to severe cellular rejection and in 8/17 with mild cellular rejection. Positive ADCC and/or CDC assays were associated with 14/14 biopsies containing rejection vasculitis. These results suggest that selected in vitro assays may be useful in monitoring the immunologic events occurring in the rejecting allograft.Keywords
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