Na-24 space, D2O space, and blood volume in isolated dog lung

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Abstract
The pulmonary Na24, T-1824, and D2O spaces were investigated in the isolated lobe of a dog''s lung in 3 different conditions: air-filled lungs, fluid-filled lungs, and respired lungs. The T-1824 space, Na24 extravascular space, and D2O extravascular space in the air-filled lobes were . 46 [plus or minus] . 12, . 20 [plus or minus] . 10, and . 30[plus or minus] . 11, respectively. When the lobe was filled with Tyrode solution the D2O extravascular space increased more than fourfold and reflected 98% of the fluid added to the lobe, whereas the Na24 extravascular space was not altered significantly. The respired lungs yielded a T-1824 space and Na24 extravascular space of . 39 [plus or minus] . 08 and . 28[plus or minus] . 06, respectively. The data indicate that: D2O mixes completely within 2 min. with alveolar fluid, which allows almost exact prediction of the total volume of fluid in the lung; Na24 can be used to follow interstitial volume changes since its transport through the pulmonary capillary membrane is extremely rapid, whereas its transport through the alveolar membrane is almost negligible during the first 2 min; Blood is forced out of the lungs during positive pressure breathing; The interstitial spaces between the alveoli increase during lung expansion. A method was also developed to study the Na24 and D2O extravascular spaces repeatedly in the same lobe, which enable the investigator to study progressive changes in these spaces when the dynamics of the pulmonary circulation are altered.

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