Enantioselective Syn-Selective Scandium-Catalyzed Ene Reactions
- 14 May 2005
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (22) , 8006-8007
- https://doi.org/10.1021/ja0522130
Abstract
An enantio- and diastereoselective carbonyl-ene reaction catalyzed by chiral scandium pyridyl bis(oxazoline) (pybox) complexes has been developed. Uniformly high enantiomeric excesses and good yields were observed. Use of trisubstituted olefins generated the syn product in high enantio- and diastereoselectivity.Keywords
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