Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists: Orally Efficacious Antiobesity Therapeutics
- 23 February 2005
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 48 (7) , 2274-2277
- https://doi.org/10.1021/jm049035q
Abstract
Melanin concentrating hormone (MCH) is involved in regulation of food intake and energy homeostasis. Antagonists of the MCH receptor are expected to affect food intake and weight gain, making MCH-R1 an attractive target for obesity treatment. Herein, we report the discovery of a novel, orally active series of MCH-R1 antagonists that exhibit in vivo efficacy in rodent obesity models.Keywords
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