PENICILLIN IN THE TREATMENT OF NEUROSYPHILIS

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Abstract
During the twenty-six months between Feb. 1, 1944, and April 1, 1946, 236 patients with neurosyphilis were treated with penicillin at the Boston Psychopathic Hospital. Of these, 12 patients have died, follow-up of 14 patients has been lost from the clinic and 210 are now under follow-up. This report is concerned chiefly with the first 100 of the cases which have been followed one year or more after treatment. A large percentage of patients were psychotic and were regularly committed as insane. Many had been patients in other state mental hospitals and were transferred to the Boston Psychopathic Hospital for the investigative therapy. After treatment, patients were discharged to the community if clinical improvement permitted and were seen in the outpatient department for periodic examination. Otherwise, they were transferred to the Metropolitan State Hospital in Waltham, Mass., where follow-up examinations could be made by those of us who administered

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