Intravenous Aminophylline in Patients With Cystic Fibrosis
- 1 December 1980
- journal article
- research article
- Published by American Medical Association (AMA) in American Journal of Diseases of Children
- Vol. 134 (12) , 1143-1148
- https://doi.org/10.1001/archpedi.1980.02130240027009
Abstract
• Intravenous aminophylline was administered to ten patients with cystic fibrosis (CF) to determine if the medication would improve pulmonary function and to study theophylline pharmacokinetics. Intravenous normal saline was given on another day as a control. Thoracic gas volume and airway resistance, measured in a volume displacement body plethysmograph, and maximal expiratory flow-volume curves were performed before and after each infusion. No significant improvement was noted in pulmonary function after normal saline infusion. Following aminophylline infusion, significant improvement in thoracic gas volume, residual volume, specific airway conductance, and maximal expiratory flow at 60% of total lung capacity was noted. The pharmacokinetic analysis revealed a mean half-life of 4.7 hours, a total clearance of 91 mL/hr/kg, and a volume of distribution of 574 mL/kg. Intravenous aminophylline can acutely decrease airway obstruction in children with CF. (Am J Dis Child134:1143-1148, 1980)This publication has 24 references indexed in Scilit:
- Theoretical and computational basis for drug bioavailability determinations using pharmacological data. I. General considerations and proceduresJournal of Pharmacokinetics and Biopharmaceutics, 1976
- Rapid determination of theophylline in human plasma by high-pressure liquid chromatographyJournal of Pharmaceutical Sciences, 1976
- The Effect of a Nebulized Bronchodilator Administered with or without Intermittent Positive Pressure Breathing on Ventilatory Function in Children with Cystic Fibrosis and Asthma1,2American Review of Respiratory Disease, 1972
- Standards of pulmonary function in children.Published by Elsevier ,1969
- Assessment of bronchospasm in patients with cystic fibrosis.Published by Elsevier ,1969
- A Kinetic Photometric Method for Serum γ-Glutamyl TranspeptidaseClinical Chemistry, 1969
- Simple tests of ventilatory capacity in children with cystic fibrosis. I. Clinical and radiological findings in 85 patients. II. Three-year follow-up on 50 patients.Archives of Disease in Childhood, 1968
- Volume displacement body plethysmograph for respiratory measurements in human subjectsJournal of Applied Physiology, 1960
- The Effect of a Bronchodilator Aerosol on Ventilatory Capacity in Fibrocystic Disease of the PancreasArchives of Disease in Childhood, 1959
- A NEW METHOD FOR MEASURING AIRWAY RESISTANCE IN MAN USING A BODY PLETHYSMOGRAPH: VALUES IN NORMAL SUBJECTS AND IN PATIENTS WITH RESPIRATORY DISEASE 1Journal of Clinical Investigation, 1956