Scaling of antipyrine intrinsic clearance of unbound drug in 15 mammalian species
- 1 April 1984
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 9 (2) , 177-183
- https://doi.org/10.1007/bf03189622
Abstract
The intrinsic clearance of unbound drug (CLuint) for antipyrine in 15 mammalian species was characterized by an equation of the form, CLuint=ϕ1 (body weight)ϕ 2 (brain weight)ϕ 3, where thetas are constants. Maximum lifespan potential in mammals can also be characterized by an equation of this form. It is suggested that the set of genetic mechanisms regulating longevity and other constitutional characteristics in species is also linked to rates of drug metabolism. The ability to scale interspecies data in pharmacokinetics is taken as an expression of this design principle.Keywords
This publication has 17 references indexed in Scilit:
- Species Longevity as an Indicator for Extrapolation of Toxicity Data Among Placental AnimalsJournal of the American College of Toxicology, 1983
- Evolutionary Biology, Animal Behavior, Fourth-Dimensional Space, and the Raison ďEtre of Drug Metabolism and PharmacokineticsDrug Metabolism Reviews, 1983
- Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1982
- Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoinJournal of Pharmacokinetics and Biopharmaceutics, 1980
- Longevity and Aging in Vertebrate EvolutionBioScience, 1978
- Evolution of Longevity and Survival Characteristics in MammalsPublished by Springer Nature ,1978
- Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearanceJournal of Pharmacokinetics and Biopharmaceutics, 1977
- Relation of Gestation Time to Brain Weight for Placental Mammals: Implications for the Theory of Vertebrate GrowthThe American Naturalist, 1974
- Influence of Route of Administration on Drug AvailabilityJournal of Pharmaceutical Sciences, 1972
- ALLOMETRY AND SIZE IN ONTOGENY AND PHYLOGENYBiological Reviews, 1966