MALE-SPECIFIC SUPPRESSION OF LOCAL GRAFT-VERSUS-HOST REACTION BY PREIMMUNIZATION OF F1 HYBRID FEMALE RATS WITH MALE-SPECIFIC (H-Y) ANTIGENS

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Abstract
A quantitative graft-vs.-host (GVH) assay was developed by utilizing the relationship between the number of parental strain lymphoid cells injected into the footpad of F1 hybrid rats and the resulting weight of the popliteal lymph node. Previous immunization of female F1 hybrid rats with bone marrow cells from either parental strain male rats tolerant of F1 hybrid tissues, or F1 hybrid male rats, interfered with their ability to sustain GVH reactions after challenge with lymphocytes from parental strain male rats. The capacity of lymphocytes from parental strain male rats to evoke GVH responses can be suppressed in a situation where the production of anti-RS [recognition structure] antibodies can be excluded. The operation of an allogeneic effect is not required to achieve immunization.

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