STIMULATION OF RAT GASTRIC ADENYLATE CYCLASE BY HISTAMINE AND HISTAMINE ANALOGUES AND BLOCKADE BY BURIMAMIDE
Open Access
- 1 September 1974
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 52 (1) , 104-106
- https://doi.org/10.1111/j.1476-5381.1974.tb09694.x
Abstract
Histamine, 4-methylhistamine, 3-(β-aminoethyl)-1,2,4 triazole and betazole, in that order, stimulated adenylate cyclase prepared from rat gastric tissue in a dose-dependent manner. Burimamide, an H2-receptor blocking agent, in concentrations of 1–5 × 10−6 m antagonized this effect. The data lend some support to the hypothesis that elevated levels of cyclic adenosine 3′,5′-monophosphate may be involved in histamine-stimulated gastric secretions and that H2-receptors are associated with adenylate cyclase.Keywords
This publication has 14 references indexed in Scilit:
- Blockade by burimamide of the effects of histamine and histamine analogues on cardiac adenylate cyclaseJournal of Pharmacy and Pharmacology, 1974
- Blockade of Cardiac Histamine Receptors by PromethazineCanadian Journal of Physiology and Pharmacology, 1974
- Increased production of cyclic AMP in gastric tissue by stimulation of histamine2 (H2)-receptorsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1973
- Histamine effects on cardiac contractility, phosphorylase and adenyl cyclaseJournal of Molecular and Cellular Cardiology, 1972
- EFFECTS IN MAN OF HISTAMINE H2-RECEPTOR BLOCKADE BY BURIMAMIDEThe Lancet, 1972
- Definition and Antagonism of Histamine H2-receptorsNature, 1972
- THE ROLE OF CYCLIC AMP IN GASTRIC SECRETION*Annals of the New York Academy of Sciences, 1971
- A Protein Binding Assay for Adenosine 3′:5′-Cyclic MonophosphateProceedings of the National Academy of Sciences, 1970
- Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)Circulation, 1968
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951