Probability of Establishing Chimeric Plasmids in Natural Populations of Bacteria

8 April 1977

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 196 (4286) , 218-220
https://doi.org/10.1126/science.847470

Abstract

Formulas for estimating the probability that chimeric plasmids carried by disarmed hosts will become established in natural populations of bacteria are presented and their use illustrated with a series of realistic numerical examples. The implications of these a priori probability estimates for the problem of containment for recombinant DNA research is discussed.

This publication has 2 references indexed in Scilit:

GENETIC MANIPULATION OF MICROORGANISMS: POTENTIAL BENEFITS AND BIOHAZARDS
Annual Review of Microbiology, 1976
Stochastic Population Theories
Published by Springer Nature ,1974