Chromatolysis and vacuolation of specific diencephalic nuclei induced by acute pyrexia

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Abstract
To determine the effects of high body temperature upon cells of the central nervous system, chicks were exposed to radiant heat. An increase in body temperature 3°C above normal resulted in chromatolysis and vacuolation in the cells of the nucleus rotundum, the nucleus entopeduncularis inferior and nucleus anterior medialis of the hypothalamus. A decrease in body temperature 15°C below normal had no effect upon these cells. It is suggested that the nuclei affected by the induced acute pyrexia may be involved in sensing and responding to the specific thermal overload.

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