SmD1 Is Required for Spliced Leader RNA Biogenesis
- 1 February 2004
- journal article
- Published by American Society for Microbiology in Eukaryotic Cell
- Vol. 3 (1) , 241-244
- https://doi.org/10.1128/ec.3.1.241-244.2004
Abstract
The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans -splicing competence. In Trypanosoma brucei , RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3′-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U 28 pseudouridylation was unaffected.Keywords
This publication has 22 references indexed in Scilit:
- The Leishmania tarentolae Spliced Leader Contains Determinants for Association with PolysomesJournal of Biological Chemistry, 2003
- Exportin 1 Mediates Nuclear Export of the Kinetoplastid Spliced Leader RNAEukaryotic Cell, 2003
- On the Role of Exon and Intron Sequences intrans-Splicing Utilization and cap 4 Modification of the Trypanosomatid Leptomonas collosoma SL RNAJournal of Biological Chemistry, 2002
- Stoichiometry of the Sm proteins in yeast spliceosomal snRNPs supports the heptamer ring model of the core domain11Edited by T. RichmondJournal of Molecular Biology, 2001
- Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particleNature, 2001
- Cotranscriptional Cap 4 Formation on the Trypanosoma brucei Spliced Leader RNAJournal of Biological Chemistry, 2000
- The SLA RNA gene of Trypanosoma brucei is organized in a tandem array which encodes several small RNAsMolecular and Biochemical Parasitology, 1996
- Four newly located pseudouridylate residues in Escherichia coli 23S ribosomal RNA are all at the peptidyltransferase center: Analysis by the application of a new sequencing techniqueBiochemistry, 1993
- The U2 RNA analogue ofTrypanosoma brucei gambiense: implications for a splicing mechanism in trypanosomesNucleic Acids Research, 1986
- Tandem repetition of the 5′ mini-exon of variant surface glycoprotein genes: A multiple promoter for VSG gene transcription?Cell, 1983