Uremic Lipemia

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Abstract
Basal plasma triglyceride (TG) concentrations were increased in 13 patients with non-nephrotic uremia who were not receiving dialysis therapy (164 ± 62 mg/100 ml, mean ± SD) and 25 uremic patients who were undergoing dialysis (276 ± 250 mg/100 ml). Basal immunoreactive insulin levels of both uremic groups were higher than nonuremic subjects of the same weight. In the group undergoing dialysis triglyceride and immunoreactive insulin (IRI) were directly related (r = 0.58, P < 0.02), which suggests that increased hepatic synthesis of triglyceride-rich lipoprotein may contribute to triglyceride elevation in uremia. In addition, peak postheparin lipolytic activity, an indirect estimate of tissue lipoprotein lipase and triglyceride removal capacity, was subnormal in all uremic subjects. Hypertriglyceridemia appears to be a previously unrecognized consequence of non nephrotic uremia. Alteration in both triglyceride production and assimilation may contribute to this abnormality.