Effects of 5-Hydroxytryptophan on Schizophrenia

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Abstract
The present investigation represents a logical continuation of a previous experiment where it was shown that the injection of 5-hydroxytryptophan (5HTP) alleviates the psychological effects of lysergic acid diethylamide (LSD-25) (Brengelmann, Pare and Sandler, 1958). LSD is of interest in psychiatry because the psychotomimetic effects of the drug bear a resemblance to schizophrenia clinically, in psychological tests and, according to Hoagland, Rinkel and Hyde (1955), in their abnormal excretion of urinary phosphate. The possibility presents itself that, in some cases of schizophrenia, the functional abnormality is similar to that produced by LSD.