Plasmin-α2-plasmin inhibitor complex in plasma of patients with disseminated intravascular coagulation

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Abstract
Plasmin‐α2‐plasmin inhibitor (α2PI) complex, an indicator of in vivo plasmin generation, was measured in the plasma of 48 patients with disseminated intravascular coagulation (DIC), by enzyme‐linked immunosorbent assay (ELISA). Plasmin‐α2PI complex was markedly elevated to 7.9 ± 4.26 mg/liter (mean ± SD) in DIC at presentation, with normal values at less than 0.8 mg/liter. The concentration of plasmin‐α2PI complex changed in parallel with the course of DIC and decreased to 1.9 ± 1.49 mg/liter (n = 28) in remission. Among various underlying disorders, DIC, in patients with acute promyelocytic leukemia, had the highest complex levels (mean 10.8 mg/liter), and septic patients had the lowest levels (mean 3.4 mg/liter). No significant correlation was found between FDP and plasmin‐α2PI complex. These results indicate that the quantitative assay of plasmin‐α2PI complex in plasma would be valuable in the assessment of hyperfibrinolysis in DIC.