Sex hormone binding globulin in arterial, and in peripheral, hepatic, renal and spermatic venous blood of children and adults

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Abstract
Human sex hormone binding globulin (SHBG) was measured in arterial serum and in serum obtained from different venous territories. In 6 children, SHBG ranged from 44.4 ± 4.8 (mean ± sd) in arterial blood to 55.3 ± 5.3 in the hepatic vein (P < 0.01), while it did not change significantly in renal or peripheral tissue venous blood. In 6 male adults, no significant arteriovenous differences were found either in the peripheral tissues or in the splanchnic circulation. In the spermatic vein of 8 subjects, SHGB was significantly lower (17.1 ± 5.7) than in the arterial blood (22.8 ± 7.5), P < 0.025. The arterio-venous difference found in the splanchnic circulation of children supports the hepatic origin of SHBG, and also suggests extra-hepatic clearance of the binding globulin. Testicular uptake of SHBG might be necessary to regulate delivery of androgens to Sertoli cells in the seminiferous tubules.

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