Paget's Disease—Active or Quiescent?

Abstract
Eight out of 20 patients suffering from Paget's disease showed radiological deterioration within the space of two years. In each of these cases there was local osteoporosis at the site of the progressive changes, viz. osteoporosis circumscripta (3), demarcation zone pathological fracture (2), incomplete fractures (2), pathological fracture in porotic bone (1). These features did not occur in any of the “quiescent” patients and we believe that they are closely related to activity of the disease and that they support the contention that bone destruction is the essential, earliest and most active phase of Paget's disease.

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