International Federation of Clinical Chemistry study on the standardization of apolipoproteins A-l and B

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Abstract
This paper presents an overview on the project of the International Federation of Clinical Chemistry Committee on Apolipoproteins to standardize the measurement of apolipoproteins A-l and B. The aims of this study, performed in collaboration with the major companies manufacturing instruments and/or reagents for apolipoprotein determination, were to select and evaluate reference materials suitable for consideration as international reference materials and to standardize commercially available methods by a common accuracy-based calibration. Preliminary results indicate that uniformity of calibration results in comparability of apolipoprotein A-l and B values on serum samples.