Autosomal Dominant Gene Transmission in a Large Kindred with Gilles de la Tourette Syndrome
- 1 June 1992
- journal article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 160 (6) , 845-849
- https://doi.org/10.1192/bjp.160.6.845
Abstract
A multiplex kindred ascertained through a single proband with GTS has been systematically investigated with standardised diagnostic instruments for other cases of GTS and related disorders. Complex segregation analysis supported the hypothesis that a single major gene inherited in autosomal dominant fashion but with incomplete penetrance contributed most of the variance in the liability to develop GTS and related disorders. This result is consistent with previous segregation analyses which have employed different methods of ascertainment, and tends to confirm that a proportion of GTS is due to a dominant gene and is suitable for investigation with genetic markers for linkage analysis.Keywords
This publication has 10 references indexed in Scilit:
- Familial Tourette's Syndrome in a Large British PedigreeThe British Journal of Psychiatry, 1990
- Segregation and Linkage Analyses of Tourette's Syndrome and Related DisordersJournal of the American Academy of Child & Adolescent Psychiatry, 1990
- The Gilles de la Tourette Syndrome: the Current StatusThe British Journal of Psychiatry, 1989
- Tics and HeredityThe British Journal of Psychiatry, 1987
- The Inheritance of Gilles de la Tourette's Syndrome and Associated BehaviorsNew England Journal of Medicine, 1986
- Familial Tourette's syndromeNeurology, 1986
- A Twin Study of Tourette SyndromeArchives of General Psychiatry, 1985
- Complex Segregation Analysis with PointersHuman Heredity, 1981
- Familial tourette syndromeAnnals of Neurology, 1979