MECHANISMS OF DESOXYCORTICOSTERONE ACTION: EFFECTS OF THE WATER-SOLUBLE GLYCOSIDE ON HUMAN CIRCULATORY AND RENAL FUNCTIONS

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Abstract
THE actions of the salt-active corticosteroids include a number of apparent inconsistencies. Contradictory effects have been reported in relation to water excretion, sodium excretion and glomerular filtration rate. Desoxycorticosterone acetate (DCA) may be considered as representative of the salt-active corticosteroids. DCA injection increases both the diuretic response to water administration (Selye and Bassett, 1940) and the net daily water exchange (Green, 1948), yet its prolonged administration is followed by water retention and edema (Ferrebee, Ragan, Atchley and Loeb, 1939). Insufficiency of the salt-active corticosteroids, as observed in the adrenalectomized animal or the patient with Addison’s disease, is characterized by inability to increase urine output in response to water loading (Robinson, Power and Kepler, 1941). Nevertheless, chronic water output is relatively excessive and the tendency to dehydration is marked. The influence of salt-active corticosteroids on sodium excretion is more consistent; the usual immediate effect of DCA is sodium retention (Thorn, Engel and Eisenberg, 1939).

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