TREATMENT OF ALCOHOLISM WITH TETRAETHYLTHIURAM DISULFIDE (Antabus®)
- 2 April 1949
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 139 (14) , 918-922
- https://doi.org/10.1001/jama.1949.02900310022006
Abstract
During some experiments performed with tetraethylthiuram disulfide (antabus®) in the laboratory, Dr. Jens Hald and one of us (E. J.) discovered that persons who have ingested this substance showed symptoms after consumption of alcohol which differed quantitatively and qualitatively from the common picture of alcoholic intoxication. The discomfort after alcohol consumption in persons treated with tetraethylthiuram disulfide was so intense that we decided to submit this drug to trial as a remedy for alcoholism. The clinical experiments were conducted by one of us (O. M.-L.). The present report includes a short review of the results obtained in the investigations on the biochemical mechanism of this effect and of the clinical results on 100 persons with alcoholism who were treated for six to twelve months. PHARMACOLOGIC CONSIDERATIONS Tetraethylthiuram disulfide is a white, or slightly yellow, powder which is insoluble in water. It is relatively nontoxic. The fatal dose is 2 toKeywords
This publication has 0 references indexed in Scilit: