Diffusional transport modulation through reversible bilayer membranes
- 9 November 1992
- journal article
- Published by The Royal Society in Proceedings of the Royal Society of London. Series A: Mathematical and Physical Sciences
- Vol. 439 (1906) , 397-406
- https://doi.org/10.1098/rspa.1992.0157
Abstract
A new approach to attaining time invariant diffusional flux through bilayered membranes with reversible barriers has been demonstrated. The barrier has been formed by exploiting the phenomenon of volume transition in polymers. The novelty of the approach is that such bilayers can be formed in situ. A theoretical analysis shows how the desired diffusional behaviour can be achieved. The validity of the concept, as well as the quantitative predictability of the theoretical analysis, is demonstrated by experimentation on model systems. A potential application is highlighted.Keywords
This publication has 8 references indexed in Scilit:
- Matrix systems for zero-order release: facile erosion of crosslinked hydrogelsPolymer, 1992
- Concentration of macromolecules from aqueous solutions: A new swellex processChemical Engineering Science, 1992
- pH dependent zero order release from glassy hydrogels: penetration vs. diffusion controlJournal of Controlled Release, 1991
- Proton MASS-NMR: a new tool to study thermoreversible transition in hydrogelsMacromolecules, 1991
- Mass transfer in pH-sensitive hydrogelsChemical Engineering Science, 1989
- Applications of thermally reversible polymers and hydrogels in therapeutics and diagnosticsJournal of Controlled Release, 1987
- Effect of non-uniform initial drug concentration distribution on the kinetics of drug release from glassy hydrogel matricesPolymer, 1984
- A NEW APPROACH TO ACHIEVE ZERO-ORDER RELEASE KINETICS FROM DIFFUSION-CONTROLLED POLYMER MATRIX SYSTEMSPublished by Elsevier ,1980