Effects of the replacement of chloride by methylsulphate on the membrane currents in frog atrial trabeculae

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Abstract
Assuming the absolute value of the chloride equilibrium potential at about −30 mV, it was suggested that the lengthening of the action potential in methylsulphate solution might be explained by the decrease of an influx of chloride ions which should participate in the repolarization. The reduction of the diastolic depolarization rate might be due to the decrease of an outflux of chloride ions which should be involved in the inward background currents unmasked by the deactivation of the time-dependent outward currents.