Secondary prevention of vascular disease by prolonged antiplatelet treatment
- 30 January 1988
- Vol. 296 (6618) , 320-331
- https://doi.org/10.1136/bmj.296.6618.320
Abstract
Thirty one randomised trials of antiplatelet treatment for patients with a history of transient ischaemic attack, occlusive stroke, unstable angina, or myocardial infarction were identified. Six were still in progress, and the results of the remaining 25 were reviewed. They included a total of some 29 000 patients, 3000 of whom had died. Overall, allocation to antiplatelet treatment had no apparent effect on non-vascular mortality but reduced vascular mortality by 15% (SD 4%) and non-fatal vascular events (stroke or myocardial infarction) by 30% (4%). This suggested that with good compliance these treatments might reduce vascular mortality by about one sixth, other vascular events by about a third, and total vascular events by about a quarter. There was no significant difference between the effects of the different types of antiplatelet treatment tested (300-325 mg aspirin daily, higher aspirin doses, sulphinpyrazone, or high dose aspirin with dipyridamole), nor between the effects in patients with histories of cerebral or cardiac disease. Thus antiplatelet treatment can reduce the incidence of serious vascular events by about a quarter among a wide range of patients at particular risk of occlusive vascular disease. The balance of risk and benefit, however, might be different for “primary” prevention among people at low absolute risk of occlusive disease if antiplatelet treatment produced even a small increase in the incidence of cerebral haemorrhage.Keywords
This publication has 29 references indexed in Scilit:
- High-dose acetylsalicylic acid after cerebral infarction. A Swedish Cooperative Study.Stroke, 1987
- Effect of incremental doses of aspirin on bleeding time, platelet aggregation and thromboxane production in patients with cerebrovascular diseaseEuropean Journal of Clinical Investigation, 1985
- Persantine Aspirin Trial in cerebral ischemia. Part II: Endpoint results. The American-Canadian Co-Operative Study group.Stroke, 1985
- A secondary prevention, randomized trial of suloctidil in patients with a recent history of thromboembolic stroke.Stroke, 1985
- "AICLA" controlled trial of aspirin and dipyridamole in the secondary prevention of athero-thrombotic cerebral ischemia.Stroke, 1983
- A randomized trial of aspirin and sulfinpyrazone in patients with TIA.Stroke, 1982
- A Randomized, Controlled Trial of Aspirin in Persons Recovered From Myocardial InfarctionJAMA, 1980
- A Randomized Trial of Aspirin and Sulfinpyrazone in Threatened StrokeNew England Journal of Medicine, 1978
- Controlled trial of aspirin in cerebral ischemia. Part II: surgical group.Stroke, 1978
- Controlled trial of aspirin in cerebral ischemia.Stroke, 1977