Originalarbeiten: Human Serum Albumin Microspheres for Lung Imaging – Preparation and Evaluation
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Isotopenpraxis Isotopes in Environmental and Health Studies
- Vol. 14 (2) , 57-61
- https://doi.org/10.1080/10256017808544145
Abstract
Preparation of human serum albumin microspheres of well defined particle size distribution using a spinning disc aerosol generator has been investigated by the authors. A set up is described for bulk preparation of microspheres suitable for lung imaging. A simple procedure for denaturation of the microspheres by direct oven heating has been standardised. Methods for Tc99m labelling of these microspheres with high radiochemical yield and purity have been studied. Uptake and clearance of the labelled microspheres have been followed in experimental animals. Histopathological examination has been carried out to confirm biodegradability and safety of the microspheres. The microspheres have shown excellent lung uptake and have been found to be very safe for administration.Keywords
This publication has 4 references indexed in Scilit:
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- Use of the spinning disk technique to produce monodisperse microspheres of human serum albumin for labelling with radioisotopesThe International Journal of Applied Radiation and Isotopes, 1974
- Preparation of metabolizable radioactive human serum albumin microspheres for studies of the circulationThe International Journal of Applied Radiation and Isotopes, 1970
- Studies of the Circulation with Radioactive MicrospheresInvestigative Radiology, 1969