Synthesis of the Ninth Component of Guinea Pig Complement (C9) in Response to Experimentally Induced Inflammation

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Abstract
Effect of turpentine-induced inflammation on the serum content of C9 was studied in guinea pigs. A transient increase in the serum content as measured by an immunochemical method of Mancini et al. was observed in all guinea pigs suffering from inflammation. The serum C9 reached a maximum of approximately 200% of the initial serum level at 4 days after the injection of inflammatory agent. From studies involving incorporation of 14C-leucine into C9, it was shown that the rate of C9 synthesis in guinea pigs with turpentine-induced inflammation was increased significantly over that observed in normal guinea pigs.