Effect of Vagotomy on the Renal Response to Blood Volume Expansion in the Rat

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Abstract
Bilateral cervical vagotomy in the rat reduces the diuretic but not the natriuretic response to vascular expansion by infusion of whole blood. The attenuation of volume diuresis is similar to that observed in rats with intact vagus nerves but receiving an infusion of pitressin as well as the vascular expansion. The findings are consistent with the Gauer–Henry reflex, which attributes volume diuresis in part to reflex inhibition of vasopressin release, but imply that vagal afferents are not involved in volume natriuresis.