Prevention of Vascular Complications of Diabetes by Pancreatic Islet Transplantation

1 March 1976

journal article
research article
Published by American Medical Association (AMA) in Archives of Surgery

Vol. 111 (3) , 254-257
https://doi.org/10.1001/archsurg.1976.01360210048009

Abstract

• Isolated pancreatic islets from Wistar-Lewis rats were transplanted into the liver of diabetic allogeneic recipients to assess ability to prevent diabetic renal and ophthalmic complications. At nine months, the diabetic animals without transplants showed significant increase in PAS-positive material in the renal glomerular mesangium and thickening of glomerular arterioles as compared with normal nondiabetic animals. New vessel formation was also significant in the retina and retinal capillary dilation. Animals in which diabetes had been corrected by early pancreatic islet transplantation were completely protected from these changes, showing no significant pathologic change when compared with normal animals. (Arch Surg 111:254-257, 1976)

Keywords

This publication has 1 reference indexed in Scilit:

Isolation and culture of the islets of Langerhans of the guinea pig
General and Comparative Endocrinology, 1965