Aldisine Alkaloids from the Philippine Sponge Stylissa massa Are Potent Inhibitors of Mitogen-Activated Protein Kinase Kinase-1 (MEK-1)
- 15 December 2001
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 45 (2) , 529-532
- https://doi.org/10.1021/jm0102856
Abstract
Read the full review for this F1000Prime recommended article: Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).Keywords
This publication has 11 references indexed in Scilit:
- An Enzyme-Linked Immunosorbent Assay for the Raf/MEK1/MAPK Signaling CascadeAnalytical Biochemistry, 2001
- Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid DebromohymenialdisineJournal of Biological Chemistry, 2001
- Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsBiochemical Journal, 2000
- The discovery of potent cRaf1 kinase inhibitorsBioorganic & Medicinal Chemistry Letters, 2000
- Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituentChemistry & Biology, 2000
- A Scintillation Proximity Assay for the Raf/MEK/ERK Kinase Cascade: High-Throughput Screening and Identification of Selective Enzyme InhibitorsAnalytical Biochemistry, 1999
- Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell linesOncogene, 1997
- Mitogen-activated protein kinase pathwaysCurrent Opinion in Cell Biology, 1997
- PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in VivoJournal of Biological Chemistry, 1995
- [30] Assay of MEK kinasesPublished by Elsevier ,1995