Acquired Type I von Willebrand's Disease Associated with Highly Substituted Hydroxyethyl Starch

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Abstract
High-molecular-weight hydroxyethyl starches (hetastarches) can cause acquired type I von Willebrand's disease.1 A case has also occurred after treatment with medium-molecular-weight hydroxyethyl starches (pentastarches).2 We analyzed all patients with hemostatic disorders that occurred during treatment with pentastarch (Elohes and Hesteril, Fresenius, Paris; and Lomol, Dupont, Wilmington, Del.) and that were spontaneously reported to the 31 French regional drug-monitoring centers.