Radioautographic Investigations on DNA and Protein Metabolism in 2 Cases of Di Guglielmo’s Disease

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Abstract
H3-thymidine and H3-DL-leucine incorporation in the erythroblasts of the bone marrow from a case of acute and one of chronic Di Guglielmo’s disease was studied. A similar investigation was also carried out with bone marrow from 4 normal subjects. The high resolution of the radioautographic technic employed allowed a comparative study at the cellular and subcellular level. A definitely lowered thymidine uptake was observed in the cells of acute erythremic myelosis, while increased incorporation of DL-leucine was detected in both the acute and the chronic form of this disease.

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